Inhibition of Drug-Sensitive and Drug-Resistant Mycobacterium Tuberculosis Strains by Essential Oil from Croton Argyrophylloides Mull. Arg.


  • Jose Antonio Barreto Alves Federal University of Sergipe
  • Mariangela da Silva Nunes
  • Ricardo Fakhouri
  • Paulo Ricardo Saquete Martins-Filho
  • Maria do Carmo de Oliveira Ribeiro
  • Alberto Correa de Vasconcellos
  • Patricia Oliveira Santos
  • Murilo Marchioro
  • Rita de Cassia Trindade
  • Gladslene Goes Santos Frazão
  • Andreia Centenaro Vaez
  • Karine Vaccaro Tako



Objetcitve: To assess in vitro effects of essential oil extracted from Croton argyrophylloides against clinical and standard strains of Mycobacterium tuberculosis, comparing its resistance and sensitivity profiles to drugs commonly used in therapy.

Method: In the present study, chemical composition and antimycobacterial activity of essential oils extracted from aerial parts of Croton argyrophylloides collected in Curituba district, Sergipe, Brazil were analysed. The oil was studied by GC and GC-MS and its antimicobacterial activity (MIC) was tested against 49 clinical and standard covers H37RV using the REMA method. To access sensitivity to isoniazid, rifampicin, ethambutol and streptomycin it was used proportions indirect test method.  

Results: Twenty-seven chemicals were identified, totalizing 95.98% of the composition of essential oil. The oil presented good antibacterial activity (MIC = 97 to 195 g / ml) against strains of Mycobacterium tuberculosis H37Rv and pattern one.

Conclusion: On pharmacological activities of these species confirmed in vitro scientific support for its use in traditional herbal preparations.






Laboratory Medicine

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