Ethnopharmacological and Genetic Study on the Treatment of Mental Disorders: a Systematic Review
Keywords:Treatment of Mental Disorders, Ethnopharmacological, Genetic Study
Background: Popular medicine has been used to treat some diseasesÂ including mental disorders since the ancient times. The developmentÂ of this powerful tool can bring to the actual world some benefis toÂ improve the way of taking care of mental illnesses.
Objective: To show relevant studies about biopharmaceuticals andÂ to infer the equivalence of using biopharmaceuticals, regarding toÂ efficiacy and safety as the chemical-type drugs in the treatment forÂ mental disorders, assessing whether there are biomolecules thatÂ might work as biopharmaceuticals to treat, cure or mitigate different mental disorders.
Methods: A systematic review from 01.01.2004 to 25.28.2014 wasÂ performed on the databases PubMed, Scopus and Science Direct.Â The search was performed with the descriptor ''mental disorders''Â and with the keywords ''biopharmaceuticals'' and ''biomolecules''.Â The information pertinent to the study was selected, categorized andÂ analyzed. Of the 339 articles found, 20 met the eligibility criteria.
Results: Eastern culture, followed by Amazonian region concentratedÂ most of the species related with popular treatment of mental disorders. Several species were revealed to act upon receptors or neurotransmitters in the Central Nervous System (CNS), which, sometimes, isÂ a similar mechanism of action of a lot of well-known synthetic drugsÂ on the market. It was also highlighted the use of the genetic knowledge to propose a gene therapy, in which a more targeted treatment would be available in cases of mental illnesses.
Conclusion: Our fidings consolidate the importance of popularÂ medicine to society. In this study, the reported natural compoundsÂ have been used for many years to treat mental disorders confimingÂ their potential activity as biopharmaceuticals. Also, possible targetsÂ were reported for gene therapy, a promising approach to treat mentalÂ illnesses.
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