Antimicrobial Resistance and Biofilm Formation of Pseudomonas aeruginosa

A short review article


  • Abdelraouf A Elmanama Islamic University-Gaza
  • Suhaila Al-Sheboul Jordan University of Science and Technology Faculty of Applied Medical Sciences Department of Medical Laboratory Sciences
  • Renad I Abu-Dan Islamic University of Gaza Faculty of Health Sciences Medical laboratory Sciences Department



bacterial adhesion, Biofilm, Pseudomonas aeruginosa, antimicrobial resistance, quorum sensing


Pseudomonas aeruginosa threatens patient’s care. It is considered as the most complicated health care associated pathogen to be eliminated from infection site. The biofilm forming ability of P. aeruginosa, being a major virulence factor for most pathogenic microorganism, protects it from host immunity and contribute to antibiotic resistance of this organism. It is estimated that about 80% of infectious diseases are due to biofilm mode of growth. Biofilm forming ability of bacteria imparts antimicrobial resistance that leads to many persistent and chronic bacterial infections. The world is becoming increasingly under the threat of entering the “post-antibiotic eraâ€, an era in which the rate of death from bacterial infections is higher than from cancer.

This review focus on P. aeruginosa biofilm forming ability; definition, developmental stages, and significance. In addition, the quorum sensing and the antibiotic resistance of this pathogen is discussed.

Keywords: Biofilm; bacterial adhesion; Pseudomonas aeruginosa; antimicrobial resistance; quorum sensing.



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