Irinotecan: Electron transfer mechanism in CNS disorders: Electron affinity, ROS, and SAR

  • Peter Kovacic
  • Andrew L. Cooksy
  • Janet Cantada

Abstract

A recent article deals with promising use of irinotecan in treatment of Angelman Syndrome, a neurological disorder. The present report provides mechanistic evidence for involvement of electron transfer based on preliminary data from computational studies on electron affinity. The drug and the topotecan analog are related to camptothecin, a well­known anticancer drug. The protonated forms are better at electron affinity. Lactone hydrolysis may provide carboxyl for intramolecular protonation. The active phenol metabolits may also play a role. Structure­activity relationship (SAR) in addressed. These results buttress the prior hypothesis dealing with irinotecan mechanism in central nervous system toxicity
Published
Feb 7, 2015
How to Cite
KOVACIC, Peter; COOKSY, Andrew L.; CANTADA, Janet. Irinotecan: Electron transfer mechanism in CNS disorders: Electron affinity, ROS, and SAR. Open Journal of Medicine, [S.l.], v. 3, n. 1, feb. 2015. Available at: <http://imed.pub/ojs/index.php/ojmedicine/article/view/1028>. Date accessed: 24 aug. 2017.
Section
Articles

Keywords

irinotecan, CNS disorders, electron transfer, electron affinity calculations, SAR