An Update On Rodent Model Studies In Diabetic Neuropathy: A Brief Communication


  • Nadia Nara Rolim Lima
  • Carlos Augusto Carvalho Vasconcelos
  • Antonio Gilvan Teixeira Júnior
  • Lorenza Andres Almeida de Souza
  • Marcos Antonio Pereira de Lima
  • Randy Alan Nessler
  • Marcelo Moraes Valença



The diseases of the peripheral nerves are quite common and diversified, are directly related to several factors, ranging from the imbalance related to good nutrition and adequate needs of nutrients, going to the injuries caused by drugs or mechanisms external to the human organism. Diabetes is a complex syndrome that affects and kills millions of people worldwide. We demonstrated through the experimental model of diabetes using STZ@ in single intraperitoneal dose of 60 mg / kg, that both a purely motor nerve can be directly affected as well as a special afferent nerve (cranial nerve), this comparison showed us that there is a possibility of having a new type of mixed type neuropathy, this may be related to the amount of the dose involved, such as the time of disease progression, but more studies need to be done for definitive confirmation. We can extrapolate the original results to understand the mechanisms of diabetes in humans, although it does not yet have an experimental model of type II diabetes, more related to eating disorders, the STZ application simulates the effects of type I or insulin dependent diabetes, with more serious and deleterious effects mainly the more distal portions of the nerves. Prevention and food control are very important, especially those related to the mechanisms that involve carbohydrate metabolism and its peripheral resistance. The original results commented here are relevant for the continuous study of this serious but old illness, but quite current in the medical and therapeutic clinic.

Keywords: Experimental Model of Diabetes; Sensory and Motor Peripheral Nerves; Peripheral Nerve Injuries; Neuropathies; STZ; Rats.







Most read articles by the same author(s)

1 2 > >>