Endothelial Dysfunction in Prehypertension and Associated Factors
Background— Endothelial dysfunction precedes structural abnormalities and atherosclerosis clinical manifestations, and thus it is considered an early marker of cardiovascular diseases. The objectives of this cross-sectional study were to determine the frequency of endothelial dysfunction in prehypertensive subjects and its association with demographic, anthropometric and clinical characteristics of the population studied.
Methods and Results— Endothelial function was assessed by flow-mediated vasodilation (FMD) of the brachial artery in 60 non-smoking and non-diabetic prehypertensive subjects aged 30-70 years who were recruited from the community. Variables analyzed were gender, age, race, sedentary lifestyle, dyslipidemia, body mass index, abdominal circumference and blood pressure. In order to evaluate the relationship between endothelial dysfunction and study variables, Student t, Mann-Whitney and chi-square tests were used. Multivariate logistic regression of variables analyzed with respect to endothelial dysfunction was applied in unadjusted as well as adjusted models (p<0.20). Significance level was set at 5%. Mean age of prehypertensive subjects was 42.6±9.2 years; 60% were females, 33.3% were Black, 61.6% were overweight, and 68.3% had a sedentary lifestyle. Endothelial dysfunction was detected in 36.7% of the population; its frequency was higher for Black subjects (45%). Association was established between endothelial dysfunction and males as well as obesity, the latter even after adjustment of the model (p=0.010).
Conclusions— In conclusion, frequency of endothelial dysfunction as determined by FMD was high in the population under study, even though subjects were young, non-smoking and non-diabetic, and association was established between endothelial dysfunction and obesity.
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