Role of Sodium Glucose Co-Transporter-2 Inhibitors in Pre-diabetes and Extra-glycemic Effects
Abstract
The burden of diabetes mellitus and pre-diabetes has been extensively increasing over the past few years. Selective sodium-glucose co-transporters inhibitors were extensively studied in type 2 diabetes mellitus and were found to have sustained urinary glucose loss, improvement in glycemic control, in addition to their proven metabolic effects. Although they sound to be promising, there is still no clear data regarding their use in the prevention of diabetes, in pre-diabetic individuals, a subset of patients who are at increased risk of development of type II diabetes and its complications. Moreover, sodium-glucose co-transporters inhibitors were found to have multiple extra-glycemic beneficial effects, including weight loss, blood pressure reduction and beneficial effects on the kidneys. Therefore, their use in pre-diabetes is postulated to be beneficial on glucose and metabolic profile and larger studies need to be conducted in this subset of population.
Keywords

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access and Benefits of Publishing Open Access).