Aloe Vera Delays Mortality, but Does Not Attenuate Kidney Injury in Septic Mice


  • Vitor Nagai Yamaki Laboratory of Experimental Surgery, University of the State of Pará, Belém, Pará, Brazil.
  • Renan Kleber Costa Teixeira Laboratory of Experimental Surgery, University of the State of Pará, Belém, Pará, Brazil.
  • Eduardo Henrique Herbster Gouveia Laboratory of Experimental Surgery, University of the State of Pará, Belém, Pará, Brazil.
  • Daniel Haber Feijó Laboratory of Experimental Surgery, University of the State of Pará, Belém, Pará, Brazil.
  • Luan Teles Ferreira de Carvalho Laboratory of Experimental Surgery, University of the State of Pará, Belém, Pará, Brazil.
  • Denilson Jose Silva Feitosa Junior Laboratory of Experimental Surgery, University of the State of Pará, Belém, Pará, Brazil.
  • André Lopes Valente Laboratory of Experimental Surgery, University of the State of Pará, Belém, Pará, Brazil.
  • Edson Yuzur Yasojima Laboratory of Experimental Surgery, University of the State of Pará, Belém, Pará, Brazil.
  • Marcus Vinicius Henriques Brito Laboratory of Experimental Surgery, University of the State of Pará, Belém, Pará, Brazil.



Aloe vera, medicinal plants, animal models, sepsis


Background: Intensive care units (ICUs) admissions due to sepsis represent 2 to 11%. Although there are well stablished  therapeutic available, it still is the major cause of death in most ICUs and the leading cause of acute kidney injury. The objective of this work was to evaluate the role of Aloe vera extract on survival rates and kidney histopathology of mice submitted to sepsis induced by cecal ligation and puncture.

Methods and Findings: Twenty six mice were distributed into four groups: Sham - surgery simulation (N=5); Control - Cecal ligation and puncture was performed (N=7); Aloe - Surgery simulation and treatment with Aloe vera extract (N=7); and Sepsis + Aloe - Cecal ligation and puncture was performed followed by treatment with Aloe vera extract (N=7). The animals were observed until death. Kidneys were analysed by histopathology. Kruskall-Wallis test was used to compare the histopathological results. Survival analysis was assessed by Kaplan-Meier statistics and compared using log rank test. A significance level of 5% was adopted. The survival time ranged from 19 hours for the Control group up to 24 hours for the animals of Sepsis + Aloe group, corresponding to a survival time of 1.26 times greater (p<0.01). There were no difference between the Sham and Aloe groups and between Control and Sepsis + Aloe groups according to the four parameters analyzed (p>0.05).

Conclusions: Aloe vera extracts delays mortality but does not attenuate kidney injury in sepsis induced by cecal ligation and puncture in mice.


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