Molecular Markers in Peripheral Blood of Patient with Acute Myocardial Infarction

  • Marcelo Rodrigues Bacci ABC MEDICAL SCHOOL( FACULDADE DE MEDICINA DO ABC )
  • Mariana Jancis Rigolo
  • Flavia Gehrke ABC Medical School
  • Neif Murad ABC Medical School
  • Livia Yadova Vasconcelos ABC Medical School
  • Fernando Luiz Affonso Fonseca ABC Medical School

Abstract

AIms: Cyclooxygenases (COX) are involved in inflammation and in prostaglandin metabolism. It is estimated that the use of blockers causes a steep rise in cardiovascular events when compared with patients who did not use them. The aim of this report is to show the association of the increase in COX-2 expression in relation to time in a patient with acute myocardial infarction (AMI). Methods:A 54-year-old black woman, hypertensive and ex-cocaine user, presented with typical precordial pain and ischemia in the anterior wall of the myocardium identified by an ECG. Serial blood collections were performed in order to evaluate COX-2 and NF-kB gene expressions. Forty days prior the event she had been submitted to percutaneous coronary angioplasty due to AMI. The coronarIography revealed stent thrombosis.Results: COX-2 and NF-kB expressions peaked in the first 24 hours after the thrombotic event. Discussion: There is an increase in COX-2 expression on atherosclerotic plaques. The use of COX-2 blockers increase the risk of ischemia given their vasoconstrictor effect, resulting in a decrease in oxygen supply to the myocardium. In sum, the increase in COX-2 expression was associated with acute coronary event in this patient.

Published
Jul 30, 2016
How to Cite
RODRIGUES BACCI, Marcelo et al. Molecular Markers in Peripheral Blood of Patient with Acute Myocardial Infarction. International Archives of Medicine, [S.l.], v. 9, july 2016. ISSN 1755-7682. Available at: <http://imed.pub/ojs/index.php/iam/article/view/1699>. Date accessed: 18 nov. 2017. doi: http://dx.doi.org/10.3823/2032.
Section
Cardiology

Keywords

cyclooxygenase; acute myocardial infarction; atherosclerosis.

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