Immunological Evidence between Schizophrenia and Toxoplasmosis: an Overview


  • Jucier Gonçalves Júnior Universidade Federal do Cariri - UFCA
  • Cláudio Gleidston Lima da Silva
  • João Vitor Cândido Pimentel
  • Modesto Leite Rolim Neto
  • Maria do Socorro Vieira dos Santos


Immunological Findings, Toxoplasmosis, Schizophrenia


Background: Recent studies have corroborated the hypothesis that T. gondii is a prime candidate in etiology of Schizophrenia, and it is now considered a possible cause of this pathology.
Results: Studies have shown that patients with schizophrenia have significantly increased levels of antibodies to T. gondii compared with healthy controls. Previous research has shown an increase in the antibody response to Toxoplasma proteins in schizophrenia and bipolar disorders. CD8 immunity is reduced in schizophrenic patients, it is conceivable that a partial loss of CD8 functionality could result in periodic reactivation of the quiescent T. gondii parasites, resulting in focal necrosis and localized inflammation (contributed by innate immune cell-produced cytokines).
Conclusion: It will be necessary more experimental researches and clinical trials giving emphasis on these correlations between Schizophrenia and Toxoplasmosis. Then design effective public policies and protocols tracking for Schizophrenia it might be a possible reality







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