Meta-Analysis And Meta-Regression Of The Prevalence Of Diabetic Peripheral Neuropathy Among Patients With Type 2 Diabetes Mellitus


  • Lidiane Ribeiro de Souza Universidade do Extremo Sul Catarinense (UNESC)
  • Debora Debiasi Universidade do Extremo Sul Catarinense (UNESC)
  • Luciane Bisognin Ceretta Universidade do Extremo Sul Catarinense (UNESC)
  • Priscyla Waleska Simões Universidade do Extremo Sul Catarinense (UNESC)
  • Lisiane Tuon Universidade do Extremo Sul Catarinense (UNESC)



Type 2 Diabetes Mellitus. Diabetic Peripheral Neuropathy. Prevalence. Systematic review. Meta-analysis. Evidence-Based Healthcare.


The aim of the present study was to investigate the prevalence of diabetic peripheral neuropathy (DPN) among patients with type 2 diabetes mellitus (DM) using a systematic review and meta-analysis. An electronic search was conducted in the PubMed, Embase, Cochrane and other databases. This search employed articles published from July 1983 to December 2014. Only cross-sectional studies conducted with individuals aged 18 to 75 years old that investigated the prevalence of DPN among type 2 DM were included. Meta-regression and sensitivity analyses were performed to investigate the sources of heterogeneity. Publication bias was assessed via funnel plots and the Begg test. The meta-analysis was performed using the R 3.1.1 software. The study selection process resulted in the inclusion of 27 articles in the meta-analysis. In total, the occurrence of DPN was investigated in 16.337 individuals with type 2 DM. The global prevalence of DPN among patients with type 2 DM was 35.78% (95% CI: 27.86-44.55%). The sensitivity analysis by continent where the studies were performed showed that the prevalence of DPN was higher in Europe (48.14%; 95% CI: 33.31-63.30%). A meta-regression analysis did not 44.91%). the any cofactors as a cause of the heterogeneity. Our data suggest that the prevalence of DPN among individuals with type 2 DM is high. Due to the impact of the complications of DPN on the quality of life of the affected patients and the cost of care for these complications, this condition should be considered a significant public health problem.


FID. Federação Internacional de Diabetes:; 2015. 6ª. Available from:

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