Massive Pulmonary Embolism Associated with Hemorrhagic Colitis: what is the Link?

  • Sahar Mouram Faculty of Medicine and Pharmacy, Rabat.
  • Hicham Sabor Faculty of Medicine and Pharmacy, Rabat.
  • Imane Mouram Faculty of Pharmacy, Seville.


Title: Deep vein thrombosis in the lower limbs and pulmonary embolism are the most common thromboembolic phenomena in patients with inflammatory bowel disease. The inflammatory and thrombotic processes are connected, creating a vicious circle. Inflammation is at least implicated in maintaining the inflammatory process in ulcerative colitis and Crohn's disease. Many factors have been investigated as determinants of the pro-thrombotic tendency such as acquired risk factors or genetic and immune abnormalities, but a unique cause has not been found. Background: We felt that this case was of interest due to the rarity of the condition and the therapeutic challenge given the high risk of bleeding and the management of anti-inflammatory and immunological treatment.  Case presentation We describe the rare case of a patient with ulcerative colitis who suffered a massive pulmonary embolism that caused shock. Despite the therapeutic challenge and the high risk of hemorrhagic complications given the underlying disease, thrombolytic treatment was administered with a good result. Conclusion: Autoimmune disorders in general should be regarded not only as inflammatory disorders, but also as hyper-coagulable disorders. This clinical observation can put the item on the necessity of establishing recommendations for prevention of embolic events in patients with hemorrhagic colitis. 

Oct 11, 2015
How to Cite
MOURAM, Sahar; SABOR, Hicham; MOURAM, Imane. Massive Pulmonary Embolism Associated with Hemorrhagic Colitis: what is the Link?. International Archives of Medicine, [S.l.], v. 8, oct. 2015. ISSN 1755-7682. Available at: <>. Date accessed: 26 may 2020. doi:


hemorrhagic colitis, pulmonary embolism, thrombolysis.