Biotechnologies applied to intracranial aneurysms


  • Patricia Bozzetto Ambrosi
  • Maria Tereza dos Santos Correia
  • Laurent Spelle
  • Jacques Moret
  • Marcelo Moraes Valença



intracranial aneurysms, flow, bioinformatics, biotechnology, biotechnologies, medical devices


Background: Despite several ongoing studies about new biotechnologies applied to intracranial aneurysms, particularly its genesis, its haemodynamic and its endovascular management; there are few studies with clinical validation until now.

Objective: To systematically review studies about biotechnologies used for the treatment of intracranial aneurysms.

Method: The authors searched the following databases: MEDLINE via PubMed (May 2014), EMBASE (May 2014), Science Citation Index Expanded (May 2014), AMED Allied Medicine (May 2014). It was considered for inclusion all studies when the role of biotechnologies and intracranial aneurysms were analysed using correlational or experimental researches.

Results: Three hundred fifty seven articles met the inclusion criteria. Most of studies were about devices, flow studies, focused on bioinformatics, or computer science. The number of such investigations have proliferated considerably during the past five years.

Conclusion: Use of  biotechnologies has raised expectations for both understanding of genesis and development of intracranial aneurysms and their strategical management. Based on current evidence, mostly small pilot trials, there are too few validated data. Refinements have dramatically improved flow studies in clinical settings.


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