Blood, Sweat, and Tears. Angiogenesis, Angiogenesis- Dependent Diseases, and Angiogenesis-Interfering Therapies

  • Dennis R.A. Mans Mans

Abstract

Accumulating evidence indicates that defects in angiogenesis - the formation of either excessive or insufficient blood vessels from an existing vasculature - play important roles in the pathogenesis of a multitude of seemingly unrelated disorders such as cancer, a number of ocular conditions, certain skin diseases, as well as impaired wound healing. These findings have led to the development of various pro- and antiangiogenic compounds and devices to treat these conditions. This article addresses a few historical highlights in the field of angiogenesis, describes the involvement of this phenomenon in the pathogenesis of a number of diseases, reflects on currently available anti- and proangiogenic therapeutic strategies, and presents a research program in Suriname aimed at the identification of plant-derived substances with potential angiogenesis-interfering properties.

Published
Jun 17, 2015
How to Cite
MANS, Dennis R.A. Mans. Blood, Sweat, and Tears. Angiogenesis, Angiogenesis- Dependent Diseases, and Angiogenesis-Interfering Therapies. International Archives of Medicine, [S.l.], v. 8, june 2015. ISSN 1755-7682. Available at: <http://imed.pub/ojs/index.php/iam/article/view/1210>. Date accessed: 18 aug. 2018.
Section
Cardiovascular Biology