Oral Provocation Test on the Diagnosis of Cow's Milk Protein Allergy in Children: Integrative Review

Authors

  • Maria do Carmo Andrade Duarte de Farias Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.
  • Loianne Pereira Araruna Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.
  • Daniel Fonsêca de Miranda Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.
  • Bárbara Carvalho Dantas Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.
  • Eliane de Sousa Leite Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.
  • Gerlane Cristinne Bertino Veras Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.
  • Kennia Sibelly Marques de Abrantes Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.
  • Geofabio Sucupira Casimiro Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.
  • Antônio Fernandes Filho Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.
  • Betânia Maria Pereira dos Santos Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.
  • Kevia Katiucia Santos Bezerra Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.
  • Anne Milane Formiga Bezerra emergency mobile service, MSU, Sousa, PB, Brazil
  • Luiz Carlos de Abreu Faculdade de Medicina do ABC, Santo André

DOI:

https://doi.org/10.3823/1741

Keywords:

Allergy, Food hypersensitivity, Cow milk, Child, Diagnosis.

Abstract

Introduction: The cow's milk protein allergy (CMPA) is considered the most prevalent food allergy in children, developing, usually, during the first three years of life and can cause gastrointestinal, respiratory and skin changes. Among the diagnostic methods used, there is the oral food challenge test. However, little used in clinical practice.

Objective: Identifying the importance of Oral Provocation Test (OPT) in the diagnostic confirmation of CMPA in children.

Method: An integrative review of studies of the last ten years, with six relevant articles related to the theme and used and described the OPT in children with suspected CMPA.

Results: The OPT is important to confirm the diagnosis, avoiding prolonged exclusion diets, nutritional risks and unnecessary expenses. The oral test with milk can be adopted as the gold standard and used as a basis for comparative studies that aims to advance the molecular diagnosis, determining the specificities and sensitivities of such tests. It can also be used with other foods. In innovative studies to determine the tolerance of dairy foods, allowing include them in the feeding of these patients during the elimination diet.

Conclusion: It is important that the OPT is performed early in the onset of symptoms suggestive of CMPA, in order to avoid prolonged exclusion diets, nutritional risks and unnecessary expenses.

Author Biographies

Maria do Carmo Andrade Duarte de Farias, Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Academic Unit of Life Sciences, Teacher training center

Loianne Pereira Araruna, Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Centro de Formação de Professores Unidade Acadêmica de Ciências da Vida

Daniel Fonsêca de Miranda, Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Centro de Formação de Professores Unidade Acadêmica de Ciências da Vida

Bárbara Carvalho Dantas, Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Centro de Formação de Professores Unidade Acadêmica de Ciências da Vida

Eliane de Sousa Leite, Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Centro de Formação de Professores Unidade Acadêmica de Ciências da Vida

Gerlane Cristinne Bertino Veras, Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Kennia Sibelly Marques de Abrantes, Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Centro de Formação de Professores Unidade Acadêmica de Ciências da Vida

Geofabio Sucupira Casimiro, Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Centro de Formação de Professores Unidade Acadêmica de Ciências da Vida

Antônio Fernandes Filho, Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Centro de Formação de Professores Unidade Acadêmica de Ciências da Vida

Betânia Maria Pereira dos Santos, Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Centro de Formação de Professores Unidade Acadêmica de Ciências da Vida

Kevia Katiucia Santos Bezerra, Federal University of Campina Grande, Cajazeiras, Paraíba, Brazil.

Centro de Formação de Professores Unidade Acadêmica de Ciências da Vida

Anne Milane Formiga Bezerra, emergency mobile service, MSU, Sousa, PB, Brazil

emergency mobile service, MSU, Sousa, PB, Brazil

Luiz Carlos de Abreu, Faculdade de Medicina do ABC, Santo André

Laboratório de Escrita Científica

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Published

2015-06-22

Issue

Vol. 8 (2015)

Section

Immunology

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