Epidemiology and antimicrobial susceptibility trends of methicillin-resistant Staphylococcus aureus in a tertiary hospital

  • Thiago César Nascimento Federal University of Juiz de Fora
  • Vânia Lúcia Silva Federal University of Juiz de Fora
  • Márcia Lucas Araújo Federal University of Juiz de Fora
  • Marina Barros Campos Federal University of Juiz de Fora
  • Alessandra Barbosa Ferreira-Machado Federal University of Juiz de Fora
  • Dennis Carvalho Ferreira Estácio de Sá University
  • Murilo Gomes Oliveira Federal University of Juiz de Fora
  • Cláudio Galuppo Diniz Federal University of Juiz de Fora

Abstract

Introduction: Staphylococcus aureus is a major cause of health care associated infections worldwide.

Objective: The aim of this work was to evaluate epidemiological characteristics and antimicrobial susceptibility of Methicillin-resistant S. aureus (MRSA) strains isolates from infections in a Brazilian tertiary hospital.

Methods: Clinical and epidemiological data of the patients were collected. Bacterial strains were isolated and identified using the classical identification tests. Antimicrobial susceptibility assays were performed using the disc-diffusion method.

Findings: A total of 590 samples of S. aureus were isolated from patients and 42.5% were characterized as MRSA. Considering the clinical specimens, most of samples were isolated from blood and tracheal secretion, catheter tip, surgical site swabs, wound secretion, exudates and urine. Overall, a high frequency of resistance was observed against ciprofloxacin, clindamycin, erythromycin, amikacin, gentamicin, trimethoprim-sulfamethoxazole, tetracycline and chloramphenicol. Association between death and multidrug-resistance in elderly patients, and death and occurrence of bacteremia by multidrug-resistant MRSA was observed.

Conclusions: Our data are highly relevant for surveillance systems and to map on a wider scale the dynamics of circulation of MRSA and raise discussions on containment strategies and rational use of empiric chemotherapy.
Published
May 25, 2015
How to Cite
NASCIMENTO, Thiago César et al. Epidemiology and antimicrobial susceptibility trends of methicillin-resistant Staphylococcus aureus in a tertiary hospital. International Archives of Medicine, [S.l.], v. 8, may 2015. ISSN 1755-7682. Available at: <http://imed.pub/ojs/index.php/iam/article/view/1134>. Date accessed: 17 jan. 2018. doi: http://dx.doi.org/10.3823/1708.
Section
Microbiology

Keywords

(Staphylococcus aureus; antimicrobial susceptibility; methicillin-resistance).