Ultrastructural aspects of cranial and peripheric nerves of cronically diabetic and malnourished rats: a short biochemical panorama

  • Ageu de Oliveira Saraiva
  • Larissa Queiroz Pontes
  • Lia Gonçalves Pinho
  • Marcus Rafael Lobo Bezerra
  • Hiroê Alencar Braga
  • Nádia Nara Rolim Lima
  • Carlos Augusto Carvalho de Vasconcelos
  • Modesto Leite Rolim Neto
  • José Luiz de Lima Filho
  • Fábio André Brayner dos Santos
  • Luiz Carlos Alves
  • Marcelo Moraes Valença

Abstract

Diabetes Mellitus is one of the most common causes of neuropathies, which can be caused by molecular imbalances that impair metabolic pathways. Studies in rats showed the importance of sirtuins (SIRT), deacetylases that use NAD+ as a cofactor, which have a widespread function in metabolism, and their relation when food deprived or calorie restricted. Additionally, diabetic neuropathy presents different structural biomarkers that cause morphological alterations in fibers that can be partially treated. SIRT1 is the principal sirtuin, which acts on hypothalamus, liver, kidney, among other organs, up regulating or down regulating the expression of some genes or enzymes crucial in the process of glucose absorption.
Published
Apr 10, 2015
How to Cite
DE OLIVEIRA SARAIVA, Ageu et al. Ultrastructural aspects of cranial and peripheric nerves of cronically diabetic and malnourished rats: a short biochemical panorama. International Archives of Medicine, [S.l.], v. 8, apr. 2015. ISSN 1755-7682. Available at: <http://imed.pub/ojs/index.php/iam/article/view/1104>. Date accessed: 19 june 2018. doi: http://dx.doi.org/10.3823/1668.
Section
Endocrinology

Keywords

Diabetes Mellitus, Neuropathy, Sirtuins, Calorie Restriction

Most read articles by the same author(s)

1 2 3 4 > >>