Ultrastructural aspects of cranial and peripheric nerves of cronically diabetic and malnourished rats: a short biochemical panorama
Abstract
Diabetes Mellitus is one of the most common causes of neuropathies, which can be caused by molecular imbalances that impair metabolic pathways. Studies in rats showed the importance of sirtuins (SIRT), deacetylases that use NAD+ as a cofactor, which have a widespread function in metabolism, and their relation when food deprived or calorie restricted. Additionally, diabetic neuropathy presents different structural biomarkers that cause morphological alterations in fibers that can be partially treated. SIRT1 is the principal sirtuin, which acts on hypothalamus, liver, kidney, among other organs, up regulating or down regulating the expression of some genes or enzymes crucial in the process of glucose absorption.
Published
Apr 10, 2015
How to Cite
DE OLIVEIRA SARAIVA, Ageu et al.
Ultrastructural aspects of cranial and peripheric nerves of cronically diabetic and malnourished rats: a short biochemical panorama.
International Archives of Medicine, [S.l.], v. 8, apr. 2015.
ISSN 1755-7682.
Available at: <http://imed.pub/ojs/index.php/iam/article/view/1104>. Date accessed: 20 may 2019.
doi: http://dx.doi.org/10.3823/1668.
Issue
Section
Endocrinology
Keywords
Diabetes Mellitus, Neuropathy, Sirtuins, Calorie Restriction
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