Intra-Hepatic Cholangiocarcinoma Treated with GEMOX + Cetuximab Protocol

  • J. S. Sarraf Institute of Education and Reserach Oncologica Brazil Universidade Federal do Pará- UFPA
  • T. C. Puty Institute of Education and Reserach Oncologica Brazil Universidade do Estado do Pará- UEPA
  • A. V.M Besteiro Institute of Education and Reserach Oncologica Brazil Centro Universitário do Pará- CESUPA
  • G.S Jong-A-Liem Institute of Education and Reserach Oncologica Brazil Universidade do Estado do Pará - UEPA
  • M.N Mauro Institute of Education and Reserach Oncologica Brazil Universidade do Estado do Pará- UEPA
  • L.E.W de Carvalho Institute of Education and Reserach Oncologica Brazil Centro Avançado em Oncologia Oncológica Brasil

Abstract

New studies show a possible benefit of combining Gemcitabine, Oxaliplatin and Cetuximab for the treatment of intrahepatic tumors. However, there is currently no consensus on this in the literature. Hence, this article contributes to the debate by presenting a case of cholangiocarcinoma(biliary tract cancer), treated with a modified Gemcitabine, Oxaliplatin and Cetuximab protocol, which evolved to a considerable regression of the tumor and a complete radiologic response assessed by PET-CT Scan. The case report is of a female adult, who presented with a cholangiocarcinoma extending to hepatic segments V and VIII which met the unresectability criteria. She was submitted to chemotherapy,consisting of a combination of Gemcitabine, Oxaliplatin and Cetuximab for a prolonged period,followed by a maintenance interval of Cetuximabmonotherapy. After the 8th cycle, the patient presented better hepatic biomarker levels; after 12months of treatment, she presented a PET-CT scan showing complete radiologic response; after 15 months of treatment, an MRI scanshowed a reduced and resectable tumor. Our case report suggests use of theGemcitabine + Oxaliplatin(GEMOX) plus Cetuximab protocol as a neoadjuvant settingfor patients with unresectable cholangiocarcinoma submitted to the GEMOX protocol, presenting a progressing disease. Additionally, our case report confirms the GEMOX plus Cetuximab protocol can be modified according to clinical response so patients can obtain maximum therapeutic gain despite minor or adverse reactions.
Published
Apr 27, 2015
How to Cite
SARRAF, J. S. et al. Intra-Hepatic Cholangiocarcinoma Treated with GEMOX + Cetuximab Protocol. International Archives of Medicine, [S.l.], v. 8, apr. 2015. ISSN 1755-7682. Available at: <http://imed.pub/ojs/index.php/iam/article/view/1015>. Date accessed: 03 june 2020. doi: http://dx.doi.org/10.3823/1685.
Section
Oncology

Keywords

Cholangiocarcinoma, Intrahepatic Cancer, Treatment, Case Report