Evidence-Based Progressive Passage to Reopening American Societies Post COVID-19


  • Ziad Daoud Michigan Health Clinics- Covenant Healthcare
  • Jesse McLeod
  • Offiang Francis Ikpatt
  • Magdalena Perez
  • Marcus Atkins
  • Tracy SPeyer
  • David Stockman




serology, Sars-cov-2, IgG, IgM, society opening


In the United States, the total number of confirmed reported cases of Covid-19 had reached  1.36 million with a total death of 80,574 and a total confirmed recoveries of 210,000 cases. Significant efforts have been invested to flatten the curve and control new cases appearing in the societies. Meanwhile, the governments has imposed a lockdown with the objective of controlling the transmission of the virus. The re-opening of societies is challenging and might involve threats, many of them remain unseen. We describe here a dynamic scenario to un-locking and re-opening societies using an evidence-based design, suggested by an algorithm of screening using RT-PCR and antibodies in a large population.


Philippe Colson, Jean-Marc Rolain, Jean-Christophe Lagier, Philippe Brouqui, Didier Raoult, Chloroquine and hydroxychloroquine as available weapons to fight COVID-19, International Journal of Antimicrobial Agents (2020), doi: https://doi.org/10.1016/j.ijantimicag.2020.105932

Wang, M., Cao, R., Zhang, L. et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 30, 269–271 (2020). https://doi.org/10.1038/s41422-020-0282-0

Yang, Z., Kong, W., Huang, Y. et al. A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature 428, 561–564 (2004). https://doi.org/10.1038/nature02463

Ahmed, S.F.; Quadeer, A.A.; McKay, M.R. Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies. Viruses 2020, 12, 254

A Wilder-Smith, MD, D O Freedman, MD, Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak, Journal of Travel Medicine, Volume 27, Issue 2, March 2020, taaa020, https://doi.org/10.1093/jtm/taaa020

Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020 Rui Liua, HuanHana, Fang Liubc, Zhihua Lva, Kailang Wub, Yingle Liub. Yong Fengd, Chengliang Zhu. Clinical Chimica Acta, Volume 505, June 2020, Pages 172-175, https://doi.org/10.1016/j.cca.2020.03.009