Prevalence and Clinical Significance of SEN-virus and TT- virus Infection in Chronic HCV Patients

Authors

  • Hend Abdalla EL- sayed medical microbiology &immunology department,faculty of medicine,zagazig university
  • Nahla Abd El Hamid
  • Elsaed M. Galal ElBadrawy
  • Sameh M. Abdel Monem
  • Fatma Abdelaziz Amer

DOI:

https://doi.org/10.3823/835

Keywords:

Chronic hepatitis C, SENV, TTV, Egypt

Abstract

Background: SEN virus (SENV) and Torque teno virus (TTV) are blood born viruses. Their effect on the development and progress of liver diseases is still unclear. The aim of this study was to determine the prevalence and effect of SENV and TTV among chronic hepatitis C (CHC) patients.

Patients and Methods: two hundred patients with CHC were the subjects of this work. A single blood sample was collected from each patient. Thorough clinical examination and relevant laboratory and radiological investigations were done. SENV and TTV were tested for by polymerase chain reaction (PCR).

Results: SENV was identified in 3 and TTV was found in 21 (10.5%) of patients. No statistically significant difference was detected as regards clinical status, laboratory findings or radiological examination between SENV or TTV positive and negative patients.

Conclusion: SENV and TTV exist among CHC patients. They had insignificant implications on the course or progression of liver diseases.

 

 

References

Amer FA. Large-scale hepatitis C combating campaigns in

Egypt and Georgia; past, current and future challenges. J Infect

DevCtries 2018; 12(6):404-414.

MoghaddamS,Mousavi S, Alavian S. Is SEN Virus a Major

Concern in Hemodialysis and Liver Transplantation?, Hepatitis

Monthly 2009; 9: 50-59.

Tanaka Y, Pfeiffer R, Yeo AE. PCR-probe capture hybridization

assay and statistical model for SEN virus prevalence estimation.

J Med Virol 2004; 73(1):123-30.

Rizvi M, Jahan S, Azam M, Ajmal MR, Shukla I, Malik A, et al.

Prevalence and assessment of role of SEN virus in acute and

chronic hepatitis in India. Tropic Gastroenterl 2013; 34(4): 227-

Azimeh SH and Bouzari M. Detection of SENV Virus in Healthy,

Hepatitis B- and Hepatitis C-Infected Individuals in Yazd Province,

Iran. Iran Biomed J 2016; 20(3):168-174.

Sharifi Z, Mahmoodian-Shooshtari M, Talebian A. The Prevalence

of SEN Virus Infection in Blood Donors in Iran. Arch Iranian Med

; 11(4):423- 426.

Akiba J, Umemura T, Alter HJ, Kojiro M, Tabor E. SEN virus:

epidemiology and characteristics of a transfusion-transmitted

virus. Trandusion 2005; 45:1084-1088.

Spandole S, Cimponeriu D, Mariana LB, Mihaescu G. Human

anelloviruses: an update of molecular, epidemiological and

clinical aspects. Arch Virol2015; 160:893-908.

Pirovano S, Bellinzoni M, Matteelli A, Ballerini C, Albertini A,

Imberti L. High prevalence of a variant of SENV in intravenous

drug user HIV-infected patients 2002; 68(1):18-23.

Karimi-Rastehkenari A and Bouzari M. High frequency of SEN

virus infection in thalassemic patients and healthy blood donors

in Iran. Virology Journal 2010; 7:1.

Amer FA. Surveillance and impact of occult hepatitis B virus, SEN

virus and TT virus among hemodialysis patients with chronic

hepatitis C virus infection in the Eastern Province of Egypt.

Joint Event on GLOBAL PHARMA SUMMIT & 2nd International

Conference on GASTROENTEROLOGY AND HEPATOLOGY,

Bangkok, Thailand. Asian J Biomed Pharmaceut 2018; DOI:

4066/2249-622X-C5-013.

Najafimemar Z, Tabarraei A, Talei G, Moradi A. Prevalence and

Genotyping of Torque Teno Virus in HBV/HIV and Chronic HBV

Patients in Iran. Iran Biomed J 2018; 22(5):338-344.

Lin JG, Goto T, Nakane K. Clinical significance of SEN-virus

on interferon response in chronic hepatitis C patients. J

Gastroenterol Hepatol 2003; 18(10):1144-1149.

Mohammad SM, Hamideh SM, Moayed SA. Is SEN Virus a Major

Concern in Hemodialysis and Liver Transplantation? Hepatitis

Monthly 2009; (9):50-59.

Dai CY, Yu ML, Chuang WL, Hou NJ, Hou C, Chen SC, et al. The

response of hepatitis C virus and TT virus to high dose and long

duration interferon-alpha therapy in naïve chronic hepatitis C

patients. Antiviral Res 2002; 53:9-18.

Moreno J, Moraleda G, Barcena R, Mateos M, Campo S.

Response of TT virus to IFN plus ribavirin treatment in patients

with chronic hepatitis C, World J Gastroenterol.2004; 10(1):

-146.

Javad MK, Yaghobi R, Iravani MS, Geramizadeh B, Moayedi J.

Association between TT Virus Infection and Cirrhosis in Liver

Transplant Patients. Hepat Mon 2015; 15 (9).

Abate ML, Manzini P, Negro F, Baldi M, Saracco G, Piantino P,

et al. Detection of hepatitis C virus RNA by reverse-transcriptase

and polymerase chain reaction: clinical applications of

quantitative analysis. ClinDiagnVirol 1994; 1(5-6):289-97.

Tanaka Y, Primi D, Wang RY. Genomic and molecular evolutionary

analysis of a newly identified infectious agent (SEN virus) and its

relationship to the TT virus family. J Infect Dis 2001; 138:359-

Ergünay K, Gürakan F, Usta Y, Yüce A, Özen H, Karabulut E,

et al. Detection of TT virus (TTV) by three frequently-used PCR

methods targeting different regions of viral genome in children

with cryptogenic hepatitis, chronic B hepatitis and Hbs carriers.

Turk J Pediatr 2008; 50:432-437.

Scotto R, Buonomo AR, Moriello NS, Maraolo AE, Zappulo

E, Pinchera B, Gentile I, et al. Real-World Efficacy and Safety

of Pangenotypic Direct Acting Antivirals Against Hepatitis

C Virus Infection. Reviews on Recent Clinical Trials 2019;

DOI:19030615465010. 2174/1574887114666

Omar M, Saad El-Din S,, Fam N, Diab M, Shemis M, Raafat M,

et al. SEN Virus Infection in Egyptian Patients With Chronic

Hepatitis C and Patients Undergoing Hemodialysis. Medscape J

Med 2008; 10(12): 290.

Elsherbiny N, Hassan E, Ahmed A, Abd El-RehimA, Abd El

Rehim N, Hassany S. Does SEN virus (SENV) infection affect

the progression of chronic hepatitis C or B among Egyptian

patients?African J Microbial Res 2015; 9(23):1504-1512.

Kao JH, Chen W, Chen PJ, Lai MY, Chen DS. SEN virus infection

in patients with chronic hepatitis C: preferential coinfection with

hepatitis C genotype 2a and no effect on response to therapy

with interferon plus ribavirin. J Infect Dis 2003; 187:307-10.

AbuOdeh R, Al-Mawlawi N, Al-Qahtani A, Bohol M, Al-Ahdal

MN, Hasan HA, et al. Detection and Genotyping of Torque Teno

Virus(TTV) in Healthy Blood Donors and Patients Infected With

HBV or HCV in Qatar. J Med l Virol 2015; 87:1184-1191.

Umemura T, Yeo AE, Sottini A, Moratto D, Tanaka Y, Wang

RY, et al. SEN virus infection and its relation to transfusionassociated

hepatitis. Hepatology 2001; 33:1303-1311.

Brandhagen DJ, Charlton MR, Gross JB. Prevalence and clinical

significance of TT-virus co-infection in patients with chronic

hepatitis C treated with interferon. Hepatology 1998; 28:367A.

Trimoulet P, Le´dinghen V, Ekouevi D, Bernard P, Merel P, Cheˆne

G, et al. TT Virus Infection During Chronic Hepatitis C . Am J

Gastroenterol 2000; 95 (7):1766-1769.

Hussain T, Manzoor S, Waheed Y, Tariq H, Hanif K . Phylogenetic

analysis of torque teno virus genome from Pakistani isolate and

incidence of co-infection among HBV/HCV infected patients.

Virol J 2012; 9:320-329.

Bostan N, Amen NE, Bokhari H. Current and Future Prospects

of Torque Teno Virus. J Vaccines Vaccin 2013, S:1. DOI:

4172/2157-7560.S1-00431.

García-Ãlvarez M, Berenguer J,Ãlvarez E, Guzmán-Fulgencio M,

Cosín J,Miralles P et al. Association of torque teno virus (TTV)

and torque teno mini virus (TTMV) with liver disease among

patients coinfected with human immunodeficiency virus and

hepatitis C virus. Eur J Clin Microbiol Infect Dis 2013; 32:289-

Rocchi J, Ricci V, Albani M, Lanini L, Andreoli E, Macera L, et

al. Torquetenovirus DNA drives proinflammatory cytokines

production and secretion by immune cells via toll-like receptor

Virology 2009; 394:235-242.

Downloads

Published

2019-07-28

Issue

Section

Articles

Most read articles by the same author(s)