Probiotics: Past, Present and Future Challenges
DOI:
https://doi.org/10.3823/816Keywords:
Side effects, Health benefit, ProbioticsAbstract
The term probiotic (prolife) is utilized to describe useful living microorganisms, intended to colonize the large bowel, when consumed in adequate amounts, they confer physiological health benefits to the host. In the last decade, probiotics have been widely used as a nutritional supplement and became a rapidly developing research topic that gained importance in medicine. Recent clinical trials have found that consumption of beneficial bacterial species can manipulate gut flora and reduce or prevent the development of certain serious diseases. This brief review article is intended to discuss the status of research on probiotics, and the value of their consumption in human health.
References
Markowiak P, Katarzyna Śliżewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients 2017; 9(9): 1021.
Doron S, Snydman D. Risk and safety of probiotics, Clin Infect Dis 2015;60 (S2) :S129–134.
West C Prescott S. Prebiotics and probiotics for prevention of allergic disease [Internet]. Diva-portal.org. 2017 [cited 8 February 2017].
Pineiro M, Asp NG, Reid G, Macfarlane S, Morelli L, Brunser O, Tuohy K. "FAO Technical meeting on prebiotics". J Clin Gastroenterol 2008; 42 : 3, 2: S156–9.
Bermúdez-Humarán LG, Langella P. Use of traditional and genetically modified probiotics in human health: what does the future hold? Microbiol Spectr 2017; 5: (5) doi: 10.1128/microbiolspec.BAD-0016-2016.
Scott K P, Antoine JM, Midtvedt T, van Hemert S. Manipulating
the gut microbiota to maintain health and treat disease. Microb Ecol. Health Dis 2015; 26:25877.
Drisko Je, Giles C, Bischoff B. Probiotics in Health Maintenance and Disease Prevention. Altern Med Rev 2003; 8(2):143-155.
Nair SM , Amalaradjou MA , Venkitanarayanan K . Antivirulence Properties of Probiotics in Combating Microbial Pathogenesis. Adv Appl Microbiol 2017; 98, 1-29.
Brown A, Valiere A. Probiotics and medical nutrition therapy. Nutr Clin Care 2004; 7;(2): 56–68.
Singh VP , Sharma J, Babu S, Rizwanulla, Singla A. Role of probiotics in health and disease: A review, J Pak Med Assoc 2013;63(2), 253-257
de Vrese M , Schrezenmeir J. Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol 2008;111:1-66.
Hemarajata P, Versalovic J. Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therap Advan Gastro 2013; 6(1):39-51.
He M , Shi B . Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics. Cell Biosci 2017; 7: 54.
Derwa Y, Gracie DJ, Hamlin PJ and Ford AC . Systematic review with meta-analysis: the efficacy of probiotics in inflammatory bowel disease. Aliment Pharmacol Ther 2017; 46:389–400.
Sears, Cynthia L. A dynamic partnership: celebrating our gut flora. Science 2005;11(5): 247-251.
Walter J, Ley R. The human gut microbiome: ecology and recent evolutionary changes. Annu Rev Microbiol 2011; 65: 411–429.
Collado M, Meriluoto J, Salminen S. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol 2007;45: 454–460.
Allen SJ, Martinez EG, Gregorio GV and Dans LF. Probiotics for treating acute infectious diarrhea. Cochrane Database of Systematic Reviews ;2010:11. Art. No.: CD003048.
McFarland Lynne. Probiotics and Diarrhea, Ann Nutr Metab 2010;57(1):10–11.
Dubey AP, Rajeshwari K, Chakravarty A, Famularo G . Use of VSL#3 in the Treatment of Rotavirus Diarrhea in Children, J Clin Gastroenterol 2008; 42(1),126–129.
Fox MJ, Ahuja KDK, Robertson IK, Ball MJ, Rajaraman E. Can probiotic yogurt prevent diarrhoea in children on antibiotics? A double-blind, randomised, placebo controlled study, BMJ Open 2015;,5:e006474.
Ojetti V, Ianiro G , Tortora A , D’Angelo G, Rienze T, et al. The Effect of Lactobacillus reuteri Supplementation in Adults with Chronic Functional Constipation: a Randomized, Double-Blind, Placebo-Controlled Trial, J Gastrointestin Liver Dis 2014;23 (4), 387-391.
Youngran Y, Jaejin L. Effect of a double-coated probiotic formulation on functional constipation in the elderly: a randomized, double blind, controlled study Arch Pharm Res2014; 38(7):1345-1350.
Liu Jin, Huang Xin-En . Efficacy of Bifidobacterium Tetragenous Viable Bacteria Tablets for Cancer Patients with Functional Constipation . APJCP 2014; 15 (23) 10241-10244.
Haghdoost M, Tahizadeh S, Montazer M, Poorshahverdi P, Ramouz A, Fakour S. Double strain probiotic effect on Helicobacter pylori infection treatment: A double-blinded randomized controlled trial. Caspian J Intern Med 2017; 8(3): 165-171.
SMC L, Ward A, Chamberlain RS. Probiotics improve the efficacy of standard triple therapy in the eradication of Helicobacter pylori: A meta-analysis. Infect Drug Resist 2016; 9:275-289.
Pakdaman M, Udani J, Jhanna M, Shahani M . The effects of the DDS-1 strain of Lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial. Nutr J 2016; 15:56.
Yoshimatsu Y, Yamada A, Furukawa Ri, Sono K, Osamura A, et al. Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis, World J Gastroenterol 2015;21(19): 5985-5994.
Fedorak R , Feagan B , Hotte N , Leddin D , Dieleman L , Petrunia D, et al. (2015), The Probiotic VSL#3 Has Anti-inflammatory Effects and Could Reduce Endoscopic Recurrence After Surgery for Crohn’s Disease. Clin Gastroenterol Hepatol 2015; 13(5) ,928–935.
Fujimori S , Tatsuguchi A, Gudis K , Kishida , Mitsui K, et al. High dose probiotic and prebiotic cotherapy for remission induction of active Crohn’s disease, J Gastroenterolo Hepatolo 2006; 22 ,1199–1204.
Ya-Hui D, Lin-Yan Q, Jie P, Jing-Yang L, Xu Qiang X, et al. The regulation of immune cells by Lactobacilli: a potential therapeutic target for anti-atherosclerosis therapy, Oncotarget 2017; 8( 35), 59915-59928.
.Ashraf R , Shah N . Immune System Stimulation by Probiotic Microorganisms. Crit Rev Food Sci Nutr2014;54:7, 938-956.
Zimmermann P, Curtis N. The influence of probiotics on vaccine responses – A systematic review. Vaccine 2018; 36: 2/ 4, 207-213.
Jespersen L, Tarnow I , Eskesen D, Morberg C , Michelsen B, et al. Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study. Am J Clin Nutr 2015;101,1188-1196.
Bosch M , Mendez M , Perez M , Farran A , Fuentes M, Cune J. Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly, Nutricion Hospitalaria 2012; 27(2), 504-509.
Rizzardini G , Eskesen D , Calder P , Capetti A , Jespersen L, et al. Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12w and Lactobacillus paracasei ssp. paracasei,L. casei 431w in an influenza vaccination model: a randomised, double-blind,placebo-controlled study. Br J Nutr 2012; 107, 876–884.
Singh VP, Sharma J, Babu S, Singla A . Role of probiotics in health and disease: A review, J Pak Med Assoc 2013;63(2), 253-257.
World Allergy Organization (WAO) White Book on Allergy: Update 2013 Editors: Ruby Pawankar Giorgio Walter Canonica Stephen T. Holgate Richard F. Lockey Michael S. Blaiss). Copyright 2013 World Allergy Organization. www.worldallergy.org/UserFiles/file/WhiteBook 2-2013-v8.
Pan SJ, Kuo CH, Lam KP, Chu YT, Wang WL, et al. . Probiotics and allergy in children--an update review. Pediatr Allergy Immunol 2010; 21:e659.
Dennis-Wall JC, Culpepper T, Carmelo Nieves C, Rowe CC,3 Burns AM, et al. Probiotics (Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2) improve rhinoconjunctivitis-specific quality of life in individuals with seasonal allergies: a double-blind, placebo-controlled, randomized trial. Am J Clin Nutr 2017;105:758–67.
Motevaseli E, Dianatpour A, Ghafouri-Fard S. The Role of Probiotics in Cancer Treatment: Emphasis on their In Vivo and In Vitro Anti-metastatic Effects Int J Mol Cell Med Spring 2017; 6 (2), 66-76.
Gamallat Y , Meyiah A , Kuugbee E , Hago A , Chiwala G, et al. Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model, Biomed Pharmacother 2016;83, 536–54.
Hibberd AA, Lyra A, Ouwehand AC, Rolny P , Lindegren H, et al. Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention. BMJ Open Gastro 2017; 4:e000145. doi:10.1136.
S Sadahiro, T Suzuki, A Tanaka, K Okada, H Kamata, et al. Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: Prospective randomized trial. Surgery 2014; 155, 493-503.
de Andrade Calaça PR , Bezerra RP , Albuquerque WWC , Porto ALF , Cavalcanti MTH. Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials. Transl Gastroenterol Hepatol 2017 ; 23;2:67.
Pendharkar S, Brandsborg E, Hammarström L, Marcotte H, Larsson P-G . Vaginal colonisation by probiotic Lactobacilli and clinical outcome in women conventionally treated for bacterial vaginosis and yeast infection, BMC Infect Dis 2015; 15, 255.
Heczko PB, Tomusiak A, Adamski P, Jakimiuk AJ, Stefański G, et al. Supplementation of standard antibiotic therapy with oral probiotics for bacterial vaginosis and aerobic vaginitis: a randomised, double-blind, placebo-controlled trial. BMC Women’s Health 2015; 15,115.
Murina F , Graziottin A , Vicariotto F , Seta F . Can Lactobacillus fermentum LF10 and Lactobacillus acidophilus LA02 in a Slow-release Vaginal Product be Useful for Prevention of Recurrent Vulvovaginal Candidiasis? A Clinical Study. J Clin Gastroenterol 2014;48 , S102–S105.
Ho M, Chang YY, Chang WC, Lin HC, Wang MH, Lin, WC. et al.Oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 to reduce Group B Streptococcus colonization in pregnant women: A randomized controlled trial. Taiwan J Obstet Gynecol. 2016;55:515–518.
Mezzasalma V, Manfrini E, Ferri E, Boccarusso M, Gennaro P, et al. Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. Arch Gynecol Obstet (2017) 295: 527.
Matsuki T, Pedron T, Regnault B, Mulet C, Hara T, et al. Epithelial cell proliferation arrest induced by lactate and acetate from Lactobacillus casei and Bifidobacterium breve. PLoS One. 2013;8:e63053.
Bermúdez-Humarán GL, Langella P. Use of Traditional and Genetically Modified Probiotics in Human Health: What Does the Future Hold? Microbiol Spect 2017; 5 no. 5.
Kim H, Rutten N, Vaart Besseling, Niers L, Choi Y, Rijkers G, et al. Probiotic supplementation influences fecal short chain fatty acids in infants at high risk for eczema. Beneficial Microbes 2015; 6(6): 783-790.
LeBlanc JG, Milani C, de Giori GS, Sesma F, van Sinderen D, Ventura M. Bacteria as vitamin suppliers to their host: a gut microbiota perspective. Curr Opin Biotechnol 2013;24:160–168.
Sanders ME, Akkermans LM, Haller D, Hammerman C, Heimbach J, et al. Safety assessment of probiotics for human use. Gut Microbes 2010;1(3):164-185.
Bailiang L, Da J, Smith E, Na Li, Fenfen Y, et al. Safety Assessment of Lactobacillus helveticus KLDS1.8701 Based on Whole Genome Sequencing and Oral Toxicity Studies. Toxins 2017; 9, 301.
Allen SJ.The potential of probiotics to prevent Clostridium difficile infection. Infect Dis Clin North Am 2015;29(1):135–144.
Sherid M, Samo S, Sulaiman S, Husein H, Sifuentes H and Sridhar S. Liver abscess and bacteremia caused by lactobacillus: role of probiotics? Case report and review of the literature. BMC Gastroenterol 2016; 16(1):138.
Meini S, Laureano R, Fani L, Tascini C, Galano A, et al. Breakthrough Lactobacillus rhamnosus GG bacteremia associated with probiotic use in an adult patient with severe active ulcerative colitis: case report and review of the literature. Infection 2015; 43(6):777-81.
Aroutcheva A, Auclair J, Frappier M, Millette M, Lolans K, de Montigny D, et al. Importance of molecular methods to determine whether a probiotic is the source of lactobacillus bacteremia. Probiot antimicrob proteins 2016; 8(1):31-40.
Brunser O . Probiotics: innocuousness, prevention and risks. Revista Chilena De Pediatria 2017; 88 (4), 534-540.
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