Antibiotic resistance rates among bacterial isolates from infected patients of intensive care unit over the period (2011-2016) in Bursa, Turkey

The Comparison Of The Antibiotic Resistance Rates

  • Sanem Karadag Gecgel Bursa Yuksek Ihtisas Training and Research Hospital
  • Necmiye Demircan Bursa Yuksek Ihtisas Training and Research Hospital

Abstract

Background: The aims of this study were to evaluate the microbiological datas for effective infection control and specific antimicrobial stewardship and to report the epidemiology of ICU-acquired infections and the local antimicrobial resistance of pathogen microorganisms.


Methods: Datas were collected between January 2011-October 2016 retrospectively from the cardiology and cardiovascular surgery patients. The identification and antimicrobial susceptibility analyses in clinical isolates of pathogen microorganisms were determined by the automatic device system.


Results: Klebsiella pneumoniae was detected increasingly resistant to imipenem (IMP) significantly (p=0.048). Acinetobacter baumanii was found increasingly resistant to amikacin (AN), gentamicin (GN), trimethoprim-sulfamethoxazole (SXT) and tetracycline (TE) significantly (p=0.045, p=0.030, p=0.006, p=0.027). There was a significantly decrease in the resistant rates of IMP, piperacillin-tazobactam (TPZ), meropenem (MEM) and ciprofloxacin (CIP) for Pseudomonas spp. (p=0.048). In all of the gram-negative microorganisms, significantly increasing resistance rates to cefepime (CEP) was detected (p=0.015). In all of the gram-positive microorganisms, significantly decreasing resistance rates to teicoplanin (TEC) was also detected (p=0.034).


Conclusion: As a result, the inadequacy of infection control measures such as hand hygiene and patient isolation to prevent transmission between patients has increased the carbapenem-resistant Klebsiella pnemoniae (CR-KP) ratio, which is frequently found in recent years in our hospital. However, preferring preemptive treatment as a result of cooperation with microbiology laboratory instead of empirical treatment with antibiotics such as carbapenem and vancomycin caused the decrease in the resistance rates of resistant microorganism.

Published
Oct 13, 2017
How to Cite
KARADAG GECGEL, Sanem; DEMIRCAN, Necmiye. Antibiotic resistance rates among bacterial isolates from infected patients of intensive care unit over the period (2011-2016) in Bursa, Turkey. The International Arabic Journal of Antimicrobial Agents, [S.l.], v. 7, n. 2, oct. 2017. ISSN 2174-9094. Available at: <http://imed.pub/ojs/index.php/IAJAA/article/view/2292>. Date accessed: 16 jan. 2021. doi: http://dx.doi.org/10.3823/0809.
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Articles